Single and triple dose treatment of Trichomonas infection of the vagina.

Both metronidazole and nimorazole (Naxogin) are highly effective in the treatment of Trichomonas infection of the vagina when given orally over a period of 5 to 7 days (Wisdom and Dunlop, 1965; Keighley, 1971; Moffett, McGill, Schofield, and Masterton, 1971; Cohen, 1971; McClean, 1972). However, Moffett and others (1971) consider that only about half those on standard oral therapy adhere correctly to treatment. Even in clinical trials of such courses, the percentage of patients failing to attend for followup has tended to be high: 21 per cent. (Evans and Catterall, 1971); 22 per cent. (McClean, 1972); 17 per cent. (Moffett and others, 1971). The aim of the present investigation was to determine the efficacy of metronidazole and nimorazole when given in short high-dose courses.